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Retarget Pro offers a very easy setup process. First, select the source character — this is the model to retarget animations FROM. Next, select the target model — this is the skeleton to retarget TO. Right-click and select “Create Retarget Profile”:
Note: Retarget Profile is a data asset that contains retargeting settings for your character models. It will be saved to the current folder.
After that, a Retarget Pro Window will open up containing previews of selected characters and retargeting settings.
Tip: To find out more about this editor window, see Retarget Window.
Now, we need to assign base poses.

Initial Poses

Both characters should have similar poses as this directly impacts retargeting quality. Retarget Pro comes with T pose Animation Clips for popular skeletons: Assign “Source” and “Target” pose clips if character look different in the preview.

Bone Chains

Scroll down to the “Bone Chain Settings” section. It displays a list of all retarget features:
Note: Retarget Pro natively supports Mixamo, Synty, Character Creator, UE/UE5, Humanoid and Quadruped skeletons out of the box.
Sometimes, the plugin may not map bones correctly — such chains will have a warning icon. To fix it, click on the feature and manually pick the bones: